The objective of this research theme is the design of molecular vectors for the selective delivery of bioactive molecules to their target inside cells. These approaches consist on the development of modified homeoproteins of therapeutic interest; on the functionalization of molecular objects such as nanobodies, nanoparticles (gold, iron oxide and liposomes) and drugs by biomolecules (synthetic ligands for receptors, membranotropic peptides, targeting peptides, protein, …) allowing their cellular uptake, organelle targeting and spatio or spatio-temporally precise activation and tracking inside cells.

Associated methodologies:

• Functionalization of nanoparticles (F. Burlina, C. Mansuy, R. Moumné, A. Walrant)
• Protein vectorization (F. Burlina, S. Sagan, A. Walrant)
• Organic synthesis for prodrug development (R. Moumné)