In line with the team’s ambition to develop innovative tools for manipulating biological systems, our research focuses on the design of responsive macromolecules based on comb-like copolymers. On one hand, these polymers are used to engineer stimuli-responsive coatings that enable control over cell adhesion, with current efforts emphasizing light as an external trigger (F. Dalier, ACS Applied Materials & Interfaces, 2018; G. Boniello, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2019). On the other hand, they are employed in the design of responsive capsules aimed at achieving spatiotemporal control over drug delivery to trigger specific cellular events (L Sixdenier, ACS Macro Letters, 2022; L Sixdenier, The Journal of Physical Chemistry Letters, 2023).